Publications

Pandit S, Agarwalla P, Song F, Jansson A, Dotti G, Brudno Y, Implantable CAR T Cell Factories Enhance Solid Tumor Treatment. Biomaterials (2024).

Pandit S, Smith BE, Birnbaum ME, Brudno Y, A biomaterial platform for T cell-specific gene delivery. Acta Biomaterialia (2024).

Moody CT, Durham PG, Dayton PA, Brudno Y, Loading Intracranial Drug-Eluting Reservoirs Across the Blood-Brain Barrier With Focused Ultrasound. Ultrasound in Medicine and Biology (2023).

VanBlunk M, Srikanth V, Pandit S, Kuznetsov AV, Brudno Y, Absorption Rate Governs Cell Transduction in Dry Macroporous Scaffolds. Biomaterials Science (2023).

VanBlunk M, Agarwalla P, Pandit S, Brudno Y, Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells. JoVE (Journal of Visualized Experiments), (187), p.e64036 (2022).

Agarwalla P, Ogunnaike EA, Ahn S, Froehlich KA, Jansson A, Ligler FS, Dotti G, Brudno Y, Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells. Nature Biotechnology, 40(8), pp.1250-1258 (2022).

Pandit S, Palvai S, Massaro NP, Pierce JG, Brudno Y. Tissue-reactive drugs enable materials-free local depots. Journal of Controlled Release, 343, 142-151 (2022).

Moody CT, Brown AE, Massaro NP, Patel AS, Agarwalla PA, Simpson AM, Brown AC, Zheng H, Pierce JG, Brudno Y. “Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture.” Acta Biomaterialia, 138, 208-217 (2021).

Palvai S, Moody CT, Pandit S, Brudno Y. “On-Demand Drug Release from Click-Refillable Drug Depots.” Molecular Pharmaceutics 18, 10:3920-3925 (2021).

Palvai K, Bhangu J, Akgun B, Moody CT, Hall DG, Brudno Y. “In vivo targeting using arylboronate/nopoldiol click conjugation.” Bioconjugate Chemistry, 31, 10, 2288-2292 (2020).

Agarwalla P, Archibong E, Ahn S, Ligler FS, Dotti G, Brudno Y. “Scaffold-mediated static transduction of T cells for CAR-T cell therapy.” Advanced Healthcare Materials, 9, 14: 2000275 (2020).

Moody CT, Palvai S, Brudno Y. “Click cross-linking improves retention and targeting of refillable alginate depots.” Acta Biomaterialia, 112: 112-121 (2020)

*McNamara SL, *Brudno Y, *Miller AB, Ham HO, Aizenberg M, Chaikof EL, Mooney DJ. “Regenerating antithrombotic surfaces through nucleic acid displacement.” ACS Biomaterials Science & Engineering, 6, 4: 2159-2166 (2020).

Adams MR, Moody CT, Sollinger S, Brudno Y. “Extracellular-matrix-anchored click motifs for specific tissue targeting.” Molecular Pharmaceutics, 17, 2:3 92-403 (2019).

Wang H, Sobral MC, Snyder T, Brudno Y, Gorantla VS, Mooney DJ. “Clickable, acid labile immunosuppressive prodrugs for in vivo targeting.” Biomaterials Science, 8, 1: 266-277 (2019).

Su T, Huang K, Ma H, Liang H, Dinh PU, Chen J, Shen D, Allen TA, Qiao L, Li Z, Hu S, Cores J, Frame BN, Young AT, Yin Q, Liu J, Qian L, Caranasos TG, Brudno Y, Ligler FS, Cheng K. “Platelet‐inspired nanocells for targeted heart repair after ischemia/reperfusion injury.” Advanced Functional Materials, 29, 1803567 (2019).

Brudno Y, Pezone MS, Snyder T, Uzun O, Moody CT, Aizenberg M, Mooney DJ. “Replenishable drug depot to combat post-resection cancer recurrence.” Biomaterials, 178: 373-382 (2018).

De Leon-Peralta EJ, Brudno Y, Kwee BJ, Mooney DJ. “Improving Wound Healing through the Use of Tetrazine-Modified Alginate.” The FASEB Journal. 30(1 Supp): 1177.10 (2016).

Brudno Y, Mooney DJ. “On-Demand Drug Delivery from Local Depots.” Journal of Controlled Release. 219: 8-17 (2015).

Brudno Y, Desai R, Kwee B, Aizenberg M, Mooney DJ. “In Vivo Targeting through Click Chemistry.” ChemMedChem. 10(4): 617-620 (2015).

Maione AG, Brudno Y, Stojadinovic O, Park, LK, Smith, A, Tellechea A, Leal EC, Kearney C, Veves A, Tomic-Canic M, Mooney DJ, Garlick JA.  “Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds.” Tissue Engineering. 21(5): 499-508 (2015).

Brudno Y*, Silva EA*, Kearney CJ, Lewin S, Aizenberg M, Mooney DJ. “Refilling Drug Delivery Depots Through the Blood” Proceedings of the National Academy of Science 111(35): 12722-7 (2014).

• This work is featured as an Editor’s Choice in Science 345 (6202):1308 (2014). This work is featured in a Science and Technology Concentrate in C&E News 92(34):22 (2014) [LINK].  This work is featured in a feature on Medical Research News in MedicalXpress [LINK]. This work is featured in an article in News and Views in Nature Nanotechnology. This work is featured in the News and Analysis section in the Materials Research Society Bulletin.

Shvartsman D, Storrie H, Lee K, Kearney CJ, Brudno Y, Ho N, Cezar CA, McCAnn CM, Anderson E, Koullias J, Tapia JC, Vandenburgh HH, Lichtman JW, Mooney DJ. “Sustained Delivery Of VEGF Activates Reinnervation And Reperfusion In Ischemic Skeletal Muscles Via NGF/GDNF Signaling” Molecular Therapy 22(7):1243-53 (2014).

Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O’Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. “Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infracted heart” Biomaterials35(25): 6850-8. (2014).

Brudno Y, Aizenberg M, Mooney DJ. “Pro-Angiogenic Factors Enhance Pericyte Function During Angiogenesis” Proceedings of the Northeast Bioengineering Conference (2014).

Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA. “Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo” PLoS ONE 8(12): e83755. (2013).

Brudno Y, Ennett AB, Chen R, Aizenberg M, Mooney DJ.  “Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors” Biomaterials 34(36): 9201-9209 (2013).

Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu S, Ecker JR, Milos PM, Agarwal S, Rao A. “Genome-Wide Mapping Of 5-Hydroxymethylcytosine In Embryonic Stem Cells” Nature 473: 394-397 (2011).

Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. “An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids” Nature Chemical Biology 6: 148-155 (2009).

• This work was featured in an article in News and Views in Nature Chemical Biology 6, 87-88 (2010), and was also featured in an article highlighting Nature Chemical Biology papers over the five-year history of the journal in Nature Chemical Biology 6, 387-389 (2010).

Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. “Conversion Of 5-Methylcytosine To 5-Hydroxymethylcytosine In Mammalian DNA By MLL Partner TET1” Science 324(5929): 930-935 (2009).

This work was featured in a Spotlight in ACS Chemical Biology 4, 315 (2009) and in a Research Highlight in Nature 458, 1080 (2009).

Brudno Y, Liu DR. “Recent Progress Toward The Templated Synthesis And Directed Evolution Of Sequence-Defined Synthetic Polymers” Chemistry & Biology 16(3): 265-276 (2009).

Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. “DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes” Journal of the American Chemical Society 130 (14): 4646 –4659 (2008).